Detailed view for EgrG_000104700

Basic information

TDR Targets ID: 589587
Echinococcus granulosus, Serine:threonine protein kinase PLK4
Source Database / ID:  GeneDB

pI: 8.7492 | Length (AA): 781 | MW (Da): 86629 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005814   centriole  
GO:0007099   centriole replication  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 269 3cok (A) 4 265 62.00 0 1 0.923907 -0.52
15 482 3soa (A) 11 431 29.00 0 1 0.604232 0.66
50 269 5loh (A) 48 836 31.00 0 1 0.66169 -0.91
284 406 2mqa (A) 23 139 9.00 0 0 0.15389 -0.31
412 647 4g7n (A) 379 595 40.00 0 1 0.619177 -0.08
414 648 4n9j (A) 588 807 38.00 0 1 0.594896 -0.23
687 777 5lhx (A) 660 741 27.00 0.00000000032 0.99 0.328517 -0.92
691 770 1mby (A) 846 914 39.00 0.027 0.11 0.0674328 1.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134726)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG7186   Sak kinase
Echinococcus granulosus EgrG_000104700   Serine:threonine protein kinase PLK4
Echinococcus multilocularis EmuJ_000104700   Serine:threonine protein kinase PLK4
Homo sapiens ENSG00000142731   polo-like kinase 4
Mus musculus ENSMUSG00000025758   polo-like kinase 4
Schistosoma japonicum Sjp_0054160   Serine/threonine-protein kinase PLK4, putative
Schistosoma japonicum Sjp_0054140   Serine/threonine-protein kinase PLK4, putative
Schistosoma mansoni Smp_079410   kinase
Schmidtea mediterranea mk4.002988.01  
Schmidtea mediterranea mk4.000854.08   Serine/threonine-protein kinase PLK4
Schmidtea mediterranea mk4.000854.09   Serine/threonine-protein kinase PLK4

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens polo-like kinase 4 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.3% 289 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 28.3% 269 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 27.6% 294 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 26.5% 298 aa Compounds References
Patiria pectinifera Cdc2 300 aa 28.3% 286 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 20.5% 308 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 31.7% 161 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 27.9% 201 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.5% 291 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 21.1% 313 aa Compounds References
Bos taurus Glycogen synthase kinase-3 beta splice variant X1 419 aa 25.9% 352 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0135 0.659 1
0.4324 0.6995 1
0.2161 0.6977 1
0.0797 0.383 0.3813
0.0003 0.5 0.5
0.3189 0.6985 1
0.0135 0.5473 1
0.0026 0.5 0.5
0.3962 0.6985 1
0.0454 0.2983 0.6652
0.2693 0.6801 0.6801
0.0132 0.3593 0.6272
0.0135 0.6552 1
0.0925 0.5866 0.6755
0.0137 0.6453 0.9912
0.0348 0.398 0.6733
0.4312 0.6988 1
0.0012 0.5 0.5
0.0117 0.3366 0.3366
0.0346 0.6769 0.8095
0.0023 0.5 0.5
0.3309 0.697 1
0.0338 0.5353 0.6743
0.1025 0.3854 0.381
0.0224 0.3064 0.3064
0.0135 0.666 1
0.0483 0.536 0.7827
0.0668 0.6964 1
0.1151 0.3435 0.3379
0.1247 0.4261 0.4489
0.4193 0.6987 1
0.0342 0.4053 0.4787
0.1436 0.3425 0.3379
0.0059 1 1
0.0332 0.398 0.6733
0.0838 0.6987 1
0.022 0.4308 0.4529
0.314 0.6993 1
0.313 0.6981 1
0.0683 0.4146 0.4873
0.0136 0.3238 0.3022
0.3728 0.6986 1
0.0032 0.5 0.5
0.116 0.3343 0.3341
0.0011 1 1
0.0351 0.5287 0.7777
0.1698 0.6959 1
0.0135 0.4221 0.431
0.0137 0.4641 0.7297
0.0098 0.3242 0.2282
0.116 0.3343 0.3341
0.0112 0.2558 0.2435
0.0335 0.4109 0.4503
0.0004 0.5 0.5
0.0459 0.5374 0.7835
0.0109 0.2891 0.2891
0.0170017 0.251258 0.251258
0.3556 0.6994 1
0.365 0.6984 1
0.0135 0.659 1
0.0328 0.338 0.338
0.0027 1 1
0.0135 0.6552 1
0.336 0.6993 1
0.0135 0.659 1
0.0119 0.3366 0.3366
0.0466 0.3315 0.322
0.0339 0.4432 0.4691
0.071 0.5744 0.985
0.3149 0.6993 1
0.4236 0.6993 1
0.0063 1 1
0.0121 0.6067 0.6812
0.3556 0.6994 1
0.349 0.4339 0.6753
0.0123 0.2901 1
0.1423 0.3428 0.3412
0.0254 0.3049 0.6331
0.0081 1 1
0.0067 0.5 0.5
0.4189 0.6986 1
0.1932 0.6972 1
0.0109 0.4058 0.4323
0.0033 1 1
0.0018 0.5 0.5
0.2758 0.6982 1
0.0022 0.5 0.5
0.1243 0.6989 1
0.034 0.3391 0.4816
0.0123 0.3041 0.2959
0.1415 0.3354 0.3309
0.0217 0.286 0.286
0.1548 0.3352 0.3338
0.0135 0.659 1
0.046 0.332 0.329
0.0135 0.3693 0.646
0.0066 0.3101 0.7874
0.0129 0.3257 0.3042
0.0599 0.5608 0.8947
0.194 0.6973 1
0.0069 0.3067 0.3067
0.0797 0.383 0.3813
0.4193 0.6987 1
0.0180091 0.271298 1
0.1247 0.4261 0.4489
0.0699 0.3317 0.3317
0.0638 0.3634 0.6797
0.0569 0.5589 0.8989
0.1587 0.6966 1
0.0039 0.5 0.5
0.4291 0.6988 1
0.3266 0.6983 1
0.0269 0.3179 0.3179
0.0362 0.444 0.7128
0.0355 0.3332 0.3332
0.0494 0.5346 0.7817
0.0036 0.5 0.5
0.0219 0.2577 0.2577
0.421286 0.736655 1
0.0136 0.2628 0.2628
0.0039 0.5 0.5
0.1011 0.3715 0.3715
0.0797 0.383 0.3813
0.1247 0.4261 0.4489
0.4324 0.6995 1
0.333 0.6989 1
0.0335 0.489 0.489
0.0135 0.659 1
0.44 0.6989 1
0.2758 0.6982 1
0.0135 0.648 1
0.3706 0.6983 1
0.2535 0.6906 1
0.1523 0.3425 0.3382
0.0016 0.5 0.5
0.0454 0.2704 0.3184
0.07 0.6038 1
0.0061 0.6883 0.6883
0.0225 0.2667 1
0.44 0.6989 1
0.0135 0.659 1
0.3035 0.6985 1
0.0012 0.5 0.5
0.2348 0.6987 1
0.0062 0.6935 0.733
0.0583 0.3431 0.4038
0.2092 0.6992 1
0.0803 0.4033 0.4032
0.1164 0.3348 0.3327
0.0231 0.4205 0.42
0.2535 0.6906 1
0.3865 0.6996 1
0.0109 0.3541 0.6332
0.0033 0.5 0.5
0.3128 0.6978 1
0.3218 0.6996 1
0.0135 0.4575 0.4352
0.1423 0.3367 0.3364
0.0681 0.4095 0.4821
0.333 0.6989 1
0.0135 0.5817 1
0.0459 0.4088 0.6831
0.0135 0.5712 0.7127
0.0478 0.2754 0.3273
0.0482 0.4045 0
0.0059 1 1
0.0063 0.7244 0
0.4312 0.6988 1
0.3865 0.6996 1
0.0348 0.3211 0.3207
0.0032 0.5 0.5
0.0012 0.5 0.5
0.0037 1 1
0.0135 0.4221 0.431
0.0115 0.2545 0.2545
0.048 0.5359 0.7825
0.0064 0.3377 0.5563
0.026 0.2581 0.258
0.0029 0.5 0.5
0.3301 0.6981 1
0.0832 0.3201 0.3201
0.0618917 0.485609 0.646487
0.158 0.6971 1
0.1423 0.3367 0.3364
0.3855 0.6984 1
0.0135 0.659 1
0.0218 0.5991 1
0.0452 0.5337 0.7811
0.3318 0.6995 1
0.313 0.6981 1
0.0007 0.5 0.5
0.0688 0.5042 0.5038
0.034 0.4694 0.4694
0.0135 0.2666 0.3138
0.2693 0.6801 0.6801
0.0229 0.2846 0.6266
0.0008 0.5 0.5
0.0135 0.659 1
0.0668 0.6964 1
0.0121 0.6454 0.688
0.3607 0.6974 1
0.336 0.6993 1
0.2159 0.3648 0.3645
0.0091 1 1
0.011 0.3099 0.3009
0.0093 0.8828 0
0.0116 0.3176 0.2796
0.0333 0.536 0.7825
0.0832 0.3201 0.3201
0.0016 0.5 0.5
0.1548 0.3352 0.3338
0.2186 0.6968 1
0.0463 0.5276 0.7769
0.0233 0.659 1
0.1153 0.3322 0.3322
0.0136 0.3247 0.3032
0.0007 0.5 0.5
0.0609 0.559 0.8896
0.0799 0.4827 0.5682
0.0231 0.4205 0.42
0.0059 1 1
0.0798 0.3824 0.3807
0.0056 1 1
0.2011 0.3521 0.3498
0.3728 0.6986 1
0.2343 0.6993 1
0.044496 0.303511 0.37329
0.2348 0.6987 1
0.2693 0.6801 0.6801
0.3038 0.6982 1
0.0092 1 1
0.1011 0.3715 0.3715
0.0135 0.659 1
0.3038 0.6982 1
0.0088 0.4477 0.4477
0.0135 0.6475 1
0.0797 0.383 0.3813
0.0135 0.659 1
0.0039 0.9485 0.9402
0.0131 0.5241 0.7575
0.0042 0.5 0.5
0.0803 0.4033 0.4032
0.0117 0.4301 0.4599
0.2535 0.6906 1
0.1247 0.4261 0.4489
0.1867 0.4067 0.4075
0.0136 0.3369 0.9937
0.0007 0.5 0.5
0.0454 0.2784 0.6115
0.1049 0.3345 0.3316
0.0479 0.5375 0.7837
0.011 0.3242 0.3051
0.0365 0.4985 0.7113
0.1247 0.4261 0.4489
0.4288 0.6984 1
0.0112 0.2573 0.2464
0.0178 0.2731 0.508
0.0338 0.5376 0.7837
0.0081 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EgrG_000104700 (Echinococcus granulosus), Serine:threonine protein kinase PLK4
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